When considering study drug discontinuation or use of rescue medication (trial product estimand results), the weight loss resulting from the use of oral semaglutide was up to 5 kg, while that associated with other active comparators ranged from 0.8 to 3.8 kg, and that associated with placebo ranged from 0.1 to + 0.6 kg [35,36,37,38,39,40]
That works at first, but as titration schedules, missed doses, injection-site changes, and notes about side effects pile up, the process becomes messy: missed steps slow down tolerance, inconsistent injection sites can cause irritation, and symptom patterns get lost in notes or memory
Kit Contents
Dosing for weight loss starts at 0.6 mg per day and is increased in weekly intervals to the full dosage of 3 mg per day, higher than the 1.8-mg dose used for diabetes
It is important to note that menstrual disorders are not listed as adverse reactions in the UK Summary of Product Characteristics (SmPCs) for either Wegovy or Saxenda, and the relationship appears complex and multifactorial
Weight loss at this stage is often modest
