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Complementary fat loss pathways Retatrutide reduces caloric intake through appetite suppression (GLP-1 and GIP) while increasing caloric expenditure through thermogenesis (glucagon)

10.1016/0165-6147(91)90609-v Trends Pharmacol

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These drugs are generally not recommended for weight loss in pregnancy for fear that they will lead to women not eating enough calories

It is expected to be licensed by the MHRA in mid-2026