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This brief summary of epithalon benefits should provide researchers with a useful starting point for identifying key areas where further research may be warranted

Sitaru C, Mihai S, Zillikens D

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Furthermore, Nrf2/HO-1 interacts with the NF-KB and JAK-STAT pathways in various contexts: Nrf2/HO-1 can reduce NF-KB phosphorylation and thereby dampen inflammation, whereas proinflammatory cytokines such as TNF- and IL-6, released following NF-KB activation, upregulate HO-1 in a feedback loop (125, 129)

**Feel free to start with the smallest amount of the peptide cream if you have more sensitive skin, or dilute it a bit with another cream or serum