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First, GLP-1 receptor agonists carry an FDA black box warning about thyroid C-cell tumors based on animal studies, and while the clinical relevance in humans remains uncertain, the warning does mean patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 should not take these medications

GLP-1s were associated with lower risk of complications for those already having a substance use disorder Among people who already had a substance use disorder, starting a GLP-1 medication was associated with fewer substance-related emergency department visits, hospital admissions, overdose events, episodes of suicidal ideation or attempts, and lower mortality (see graph below)

They were also less likely to report having a sleep duration of less than seven hours per night

Patient registry data provides valuable insights into real-world side effect patterns

Label Warnings: The official product label explicitly warns not to inject bacteriostatic water by itself into the bloodstream