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Copper-zinc imbalance and excitatory tone Low zinc removes an important brake on NMDAR activity and GABA balance

doi: 10.1083/jcb.201605110 38 DixonS

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The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types

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