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Its selectivity for NNMT (IC50 values in the low micromolar range) means it increases NAD+ by preserving nicotinamide availability rather than directly supplementing NAD+ precursors

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What the Research Says Today Modern research has shown that the "destruction" of B12 by Vitamin C is likely not a significant issue for most people at normal doses

[PubMed Citation] BACKGROUND: Antidotal doses of hydroxocobalamin are associated with transient increases in blood pressure in some animals and humans

Researchers are trying to tease out whether taking additional B12 might help people lose weight