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Date: November 16, 2025 Source: Cochrane Summary: GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility

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Nrf2 activation leads to the upregulation of detoxifying enzymes that neutralize reactive aldehydes like 4-HNE, thereby reducing their inhibitory effects on pathways such as PI3K/AKT/mTOR and Wnt/-catenin [134]

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

What you eat is just as important as how much

Small daily shifts are normal, and body weight can naturally change by about 1 to 2%