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Rymaszewska et al., 2021

In the SURMOUNT-1 trial, participants following this dosing protocol achieved mean weight reductions of 15.0% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) at 72 weeks, compared to 3.1% with placebo

More important, our data indicates a strong doseresponse relationship between serum GGT and SUA levels after adjusting for potential confounders (i.e., increased GGT serum levels independently contributed to increases in SUA levels) and this finding may have implications in clinical practice and public health interventions

Options include partial reconstitution (if feasible with your vial format), freezing portions of reconstituted solution (accepting some potency loss), or adjusting your dose higher to use everything before expiration

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