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It is synthesised within cells in two sequential ATP-dependent steps, and maintained in its biologically active reduced form (GSH) through the activity of glutathione reductase using NADPH

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In brief, in ART-nave individuals, several dopaminergic regions show prominent HIV-associated neuropathology relative to nondopaminergic areas, particularly in the SbN, PFC, and striatal substructures including the caudate nucleus, putamen, and NAc (Navia et al., 1986

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