However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])
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In a cross-sectional study carried out in Moscow, it was shown that there is a significant negative linear correlation between serum MDA levels and riboflavin intake ( Reference Kodentsova, Vrzhesinskaia and Beketova 44 )
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311 studied 258 patients with micrometastases in SLNB and performed a 20-year survival analysis, and observed no significant increase in the risk of relapse or impaired MSS when comparing patients that did undergo CLND (HR: 1.3, 95% CI: 0.82.3) and did not undergo CLND (HR: 1.2, 95% CI: 0.81.9)
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