It is most relevant during GLP-1 use or caloric deficit, when fatigue is part of the picture, with age-related NAD+ decline, or when progress stalls after a clean first month
It's best suited for athletes and high-intensity users
To maintain budget neutrality under the OPPS, the reduction in any APC's relative weights from the loss of skin substitute costs in the APC's geometric mean cost will be offset by an increase in the OPPS weight scalar
Flannery PJ, Trushina E
They may also contribute to overall metabolic wellness and lifestyle improvements
Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, Panayotou G, Waterfield MD, Ponzetto C, Pelicci PG