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We reported previously that silencing LDHB in KRAS -mutant lung cancer cell lines significantly reduced the expression of SLC7A11 11 , which is required for oncogenic RAS transformation and encodes a plasma membrane-localized cystine/glutamate antiporter that provides cysteine for GSH synthesis 22,23

doi: 10.3389/fphar.2025.1714859 74 CanforaEEJockenJWBlaakEE

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