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At retail, tirzepatide-based medications (Mounjaro/Zepbound at $1,000-1,200/month) are slightly less expensive than semaglutide-based Wegovy ($1,300/month)

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Physiological Reviews, 95(1), 1-46

Longitudinal analyses from the Phase 2 and Phase 3 trials show that the incidence of new-onset nausea and vomiting peaked during the first 4-8 weeks of treatment and then declined substantially during the maintenance phase