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Baseline liver function tests usually include measurements of: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) : enzymes that indicate liver cell damage when elevated Alkaline phosphatase (ALP) : an enzyme that may be raised in bile duct obstruction or liver disease Bilirubin : a breakdown product of red blood cells

Patients currently pay around $1,300 per month of treatment, which can be a huge barrier considering the need for life-time administration

Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy

Endocrine Reviews, 1997

Cutting the patch can disrupt the delivery mechanism and may cause overdosing

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