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GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation SUMMARY: Semaglutide & Tirzepatide works primarily by making you sick

Space the mineral apart from thyroid pills, some antibiotics, and bisphosphonates by two to four hours to protect uptake

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These newer agents have individually demonstrated CV and/or kidney benefits, and the combined use of these agents is particularly appealing due to potential mechanistic and clinical synergies [6]

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