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2.2.1 TGF- TGF- is the most potent pro-fibrotic mediator, inducing ECM, EMT, and pro-fibrotic mediators production by promoting the binding of Smad2/3 to Smad4, and driving myofibroblast differentiation to promote the PF process (Hu et al., 2018

Front Psychiatry 12 , 739 (2021)

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[9] [10] For patients with established cardiovascular disease, SGLT2 inhibitors are generally prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable

At the end of the experiment, mice were anesthetized with 1% sodium pentobarbital (60 mg/kg) intraperitoneal injection

For example, research suggests that weight gain may be particularly detrimental in Asian populations, which is why some advocate for lower BMI ranges for obesity in these ethnic groups (Shai, 2006)