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3.2.1 Death receptor pathway Also known as the extrinsic pathway, the death receptor pathway is initiated by extracellular signals

ER stress triggers three branch pathways of the UPR, involving activation of transcription factor 6 (ATF6) (Shen et al., 2005), IRE1 (Chen and Brandizzi, 2013), and PERK (Figure 1)

The enzymatic activity of eNOS relies on its dimeric configuration, which is essential for its proper function

Smoking and other toxins, diabetes, hypertension, a high-sugar diet and obesity erode this protective layer

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