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| Medication | Receptor Targets | Peak Weight Loss (Trials) | Wyoming 503A Access | |---|---|---|---| | Semaglutide 2.4 mg | GLP-1 | 14.9% at 68 wk (STEP-1) [2] | Yes | | Tirzepatide 15 mg | GIP + GLP-1 | 20.9% at 72 wk (SURMOUNT-1) [3] | Yes | | Retatrutide 12 mg | GIP + GLP-1 + Glucagon | 24.2% at 48 wk (Phase 2) [1] | Yes | The 24.2% result for retatrutide came at 48 weeks, a shorter trial duration than STEP-1 (68 weeks) or SURMOUNT-1 (72 weeks)

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