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Unlike most targeted therapies, which act by inhibiting their target, a p53-targeted therapy must reactivate the protein, restoring its wild-type (WT)-like activity

We aim for overall health improvements, addressing both physical and emotional aspects of weight management

Renal tubular transport of organic acids

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Differences in instruments, observation windows, and study populations may further contribute to inconsistency

Looking ahead, further research should aim to define the most effective combinations of pharmacotherapy and lifestyle interventions, with a focus on preserving lean mass and sustaining long-term metabolic health