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The strongest signals were seen in epigenetic measures linked to inflammation, brain, heart, blood, kidney, liver and metabolic health, suggesting that the drug may influence aging-related biology across multiple body systems

The exact cause can vary depending on lifestyle, activity, or underlying health factors

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Combining complementary mechanisms theoretically offers additive metabolic benefits, but this remains largely evidence-based inference rather than proven clinical synergy in humans

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The lipolytic effect of G49 was also found ex vivo in mice and human WAT explants and, importantly, this effect was absent in WAT explants from Gcgr / mice