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Rarely, some patients experience reduced medication tolerability that leads them to skip doses or stop therapy prematurelythis allows hunger to return

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Clinical Evidence: Nausea Rates in Tirzepatide vs Semaglutide Studies In the SURPASS clinical trial program for tirzepatide, nausea occurred in approximately 25-33% of participants across all dosing phases, with most cases classified as mild to moderate and decreasing over time

May 2015;21(2):61-7

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