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Iontophoresis and electroporation: comparisons and contrasts
Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604
Toutefois, ces donnes provenant dun modle animal, il reste ncessaire de confirmer ces effets chez lhumain avant denvisager une application clinique
Acknowledgments This study was supported in part by a grant from the State Committee for Scientific Research (KBN), Warsaw, Poland (grant No
TABLE 1 The multiple effects of growth hormone (GH) and growth hormone receptor (GHR) on mitochondrial biogenesis
