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Monitor renal function in patients reporting adverse reactions to SAXENDA that could lead to volume depletion, especially during dosage initiation and escalation [see Use in Specific Populations (8.6)]

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Discussion Hydrolysis of aromatic amide-containing compounds in vivo can lead to toxicity due to the release of aromatic amine metabolites and therefore the avoidance, or identification of, potentially problematic aromatic amide structures is clearly valuable

Abcam) according to the manufacturers specifications for both culture supernatant and cell lysates