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Data from LEAD-1 and the CORE model show that liraglutide with glimepiride reduces mortality and diabetes-related complications more than rosiglitazone with glimepiride (55)

They reduce stomach acid or prevent it from refluxing into the esophagus

There is no single best medication for every patient

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According to NICE guidance (TA875 for semaglutide and TA664 for liraglutide), GLP-1 receptor agonists for weight management should only be prescribed when specific criteria are met