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Additionally, patients taking oral prednisolone exceeding 15 mg/day, those with hypersensitivity to study medications, or those consuming antioxidants were excluded

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After 24 weeks, mean weight loss with phentermine/topiramate ER in PCOS obese women was 8%, even higher than the 6.6% Weight loss reported at 56 weeks in the general population [171] However, cardiovascular safety concerns persist for this drug, particularly in people with PCOS, who are already at increased risk for cardiovascular complications compared to the general population [172]

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So, if youre concerned about ingredient quality, testing, or certifications, it's important to be mindful of the brand