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MK 677 produces sustained elevation of both GH and IGF-1 over 24 hours with a single daily dose, but the magnitude of IGF-1 elevation is lower than direct IGF-1 LR3 administration

doi: 10.1038/s41586-020-2732-8 36 YeePPWeiYKimS-YLuTChihSYLawsonCet al

Strong CYP3A inhibitors (such as ketoconazole, itraconazole, and ritonavir) would be expected to increase orforglipron exposure, potentially necessitating dose adjustment

- Alles Gut 11 June 2017 22:13 - Siegward Ortmann - Alles Gut 18 September 2016 05:32 - Sabine Z

William Seeds, author of Peptide Protocols, recommends 100mcg administered approximately 3 hours before bedtime