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Ferroptosis at the intersection of lipid metabolism and cellular signaling

This single reaction sits at the intersection of two critical metabolic axes: The folate cycle axis: 5-MTHF is the methyl donor that MTR uses to regenerate methionine from homocysteine, simultaneously regenerating tetrahydrofolate (THF) that feeds back into one-carbon metabolism for nucleotide synthesis (thymidylate and purine biosynthesis)

doi: 10.1038/s41419-024-06807-2 197 EstcioMRIssaJ-P

Overall, there were no differences observed between dose groups, but statistical power was limited due to the small sample size in this study

Preclinical observations in animal and cell culture studies have included enhanced cellular migration, increased markers of angiogenesis, and enhanced collagen deposition