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GLP1RAs can inhibit neutral lipid accumulation, ROS generation, and (NADPH oxidase 4) NOX-4 expression in rat cardiomyocytes, thereby migrating interleukin-1 (IL-1 ) induced ROS production [57]

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In clinical studies of FDA-approved tirzepatide (Mounjaro and Zepbound), participants experienced weight loss when combined with lifestyle interventions