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Hepatitis B virus (HBV) infection can progress to life-threatening liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC)

The investigation into its use in colonic epithelial/ macrophage co-culture suggests broader epithelial repair implications

The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)

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