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A comparison of a pulse-based diet and the therapeutic lifestyle changes diet in combination with exercise and health counselling on the cardio-metabolic risk profile in women with polycystic ovary syndrome: a randomized controlled trial

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Even if the usage of E2 as a therapeutic agent for human use is controversial, targeting specific ERs in the cardiovascular system could open new and perhaps safer therapeutic options for using E2 to protect the cardiovascular system [5] (Figure 1)