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In skeletal muscle cells, SELENOW was shown to reduce the binding of 14-3-3 to a transcriptional co-activator with PDZ-binding motif (TAZ) (23), allowing TAZ translocation to the nucleus and subsequent activation of muscle cell differentiation genes (24)

Last Updated: November 2023

We suggest that this is because ipratropium is able to engage the OCTN2 aromatic cage, but is unable to form a salt bridge with R471

Thats the situation were in right now