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According to the results of the RCT for patients with monogenic obesity ( LEPR or POMC deficiency) and acquired hypothalamic obesity, setmelanotide can reduce body weight and inhibit appetite to a certain extent, and common adverse reactions include injection site reactions, skin hyperpigmentation, nausea, diarrhea, and abdominal pain, with occasional occurrences of sexual adverse reactions, depression, and suicidal ideation [51,52]

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Foods high in protein, fiber, and healthy fats can trigger the release of GLP-1, an important hormone that helps regulate blood sugar levels and promotes a feeling of fullness

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