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This study was supported by the National Institute on Drug Abuse of the National Institutes of Health (grant 1UH2DA041146-02)

The side effects are real annoying at best and debilitating at worst and can include nausea, diarrhea, cramps and abdominal pain, constipation, vomiting, gastroesophageal reflux, gastroenteritis, pancreatitis, gastroparesis, intestinal obstruction, gall bladder disease, headaches and potential risk for certain types of thyroid and endocrine cancers, among other adverse effects

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