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After it's released into your system, B12 combines with another molecule called the intrinsic factor that aids its absorption into the small intestine

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and critically human PK data (unavailable because no completed clinical trials have been published)

They counteract the inability to initiate movement and catalepsy (muscular rigidity and fixed posture regardless of external stimuli), which in turn results in significantly reduced dopaminergic cell activity that is involved in the direct pathway of movement