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By preferentially promoting cAMP-mediated intracellular pathways, thought to be central to insulin secretion and appetite regulation, this receptor bias may enhance metabolic efficacy while potentially reducing the activation of alternative signalling cascades associated with receptor desensitisation or adverse effects (although the clinical relevance of this remains to be fully established)

Mazure, N

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During the course of two experiments, l-carnitine's effects on food intake, body weight, body composition and activity output during exercise were evaluated