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High non-ceruloplasmin-bound copper can increase oxidative stress, while low zinc may impair copper regulation and SOD1/SOD3 structure

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A subsequent multicenter Phase 2 trial in participants with overweight or obesity reported approximately 15.6% mean body weight reduction at 32 weeks with cagrilintide 2.4 mg plus semaglutide 2.4 mg, compared to roughly 5.1% with placebo and lower percentages with either monotherapy

IV administration is meant for specific cases and is to be given only under medical supervision by an expert