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The remaining three studies reported no significant improvements in UPDRS scores

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Aging Clin Exp Res 28(6):12511257

Patients were randomly assigned in a 2:1 ratio to receive vandetanib or placebo.[11][Level of evidence B1] With a median follow-up of 24 months, progression-free survival (PFS) favored vandetanib (hazard ratio [HR], 0.46

It is two doses crammed into 36 hours, creating an amplified peak that will almost certainly make you feel worse

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