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Medically reviewed by: Micheal Seay, MSN, APRN, FNP-BC

Start your intake How GLP-1 Medications Trigger Nausea and Vomiting Semaglutide and tirzepatide work by activating GLP-1 receptors in your brain and digestive tract, which signals fullness and slows stomach emptying

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Certain foods, particularly high-fat or high-carbohydrate meals, can exacerbate these side effects or interfere with Semaglutide's effectiveness

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