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Transgene expression restored GLP-1Rdependent stimulation of cAMP and Akt phosphorylation in isolated islets, conferred GLP-1Rdependent stimulation of cell proliferation, and was sufficient for restoration of GLP-1stimulated insulin secretion in perifused islets

Clinically noticeable improvements in 7 days no rebound effect

doi: 10.1038/s41598-019-38956-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 94

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