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Circadian Rhythms 3 , 15 (2005)

Some studies suggest its use has been associated with an increased risk of depression, suicide, and inflammatory bowel disease

In a home setting, patients should have a designated spot in their refrigerator to store it safely (ideally in a container to avoid contact with food items and with the original box around it)

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Additional study is needed to determine benefit of these augmentation strategies, although it is hypothesized that a stronger repair can prevent loss of reduction, reduce failure, and allow for earlier postoperative mobilization