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These designs can reveal whether a ligand expresses different apparent potency or efficacy profiles across receptor states, and whether the kinetic signature changes with receptor subtype

Tirzepatide, whether for weight loss or diabetes management, should be integrated with sustainable, healthy lifestyle habits that support long-term well-being.

Med ., 18 , 1599-1611, doi: 10.1111/jcmm.12312

Animals were not used for multiple experiments as two of the three experiments were non-survival (due to the blood collection following DMRS and the urethane anesthesia used for fMRI) and incompatible (DMRS and PET both required labeled glucose injection, the DMRS and fMRI signals may interfere with each other, and fMRI required different anesthesia than the other two experiments)

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