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Min and Bain (2021) reviewed the dual-agonist pharmacology at the class level, and El et al

If B12 is the culprit, shedding stops within 36 months, with regrowth visible in 612 months

Weeks 46 : first measurable waist or body-fat changes in responders, based on research community reports

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For patients with persistent vomiting, targeted thiamine supplementation (50-100 mg daily) may be appropriate under medical supervision rather than high-dose B-complex formulations

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