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Early side effects are predominantly gastrointestinal including nausea, vomiting, and changes in bowel habit and are managed through a gradual, pre-specified dose-escalation schedule

The compounds literature base includes human randomized research, mechanistic pharmacology, receptor-structure studies, and model-system work

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Effects of glucagon-like peptide-1 receptor agonists on cardiovascular and renal outcomes: a meta-analysis and meta-regression analysis

These hormones, known collectively as incretins, are secreted by the gut in response to nutrient ingestion and play crucial roles in metabolic regulation

Weight-Related Conditions People with obesity-related conditions, such as type 2 diabetes or metabolic health concerns, are also being studied to understand potential benefits