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Mounjaro (tirzepatide) is a synthetic agonist of two essential hormones GLP-1 and GIP, therefore generally exerts a greater overall effect on appetite and metabolic function

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Evidence is limited but mixedsome studies suggest GLP-1s may have mild anti-inflammatory effects, while others flag potential immune activation risk in susceptible patients

Additionally, the activation of TGR5 and FXR (receptors for BAs) inhibits the effector functions of macrophages and promotes their polarization toward the anti-inflammatory M2 phenotype (49)

This approach minimizes nausea and digestive side effects while your body adapts to the medication

If youre considering a fasting protocol, discussing with your provider is recommended to make sure the two arent working against each other