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For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80

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A large-scale, placebo-controlled clinical study shows a remarkable benefit from adding exenatide, a short-acting GLP-1 receptor agonist, to insulin glargine, on a background of metformin and/or pioglitazone, in patients with type 2 diabetes mellitus