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PIONEER 1 to 6 and 8 to 10 have been summarized in detail for this report (details for PIONEER 7 are provided in Appendix 3 as the intervention, semaglutide with flexible dosing, is not aligned with the criteria specified in the CADTH review protocol or the dosing recommended by Health Canada)

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These modes of healing have been observed in rodents with transected Achilles tendons