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Not considered clinically important

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These changes culminated in a marked 30% decline in left ventricle ejection fraction by day 52, confirming substantial Dox-induced systolic dysfunction

Some patients report a slight warm sensation at the injection site or mild nausea in the first eveningthese sensations typically fade within hours

First-time users experience the highest symptom severity because their liver hasn't yet adapted to processing supraphysiological doses of methionine and methylcobalamin simultaneously