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Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses

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Brazil Scientific studies have found that the FOXO4-DRI peptide works by selectively inducing apoptosis in senescent cells through disruption of the interaction between FOXO4 and p53 (1)

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London, E., Bloyd, M