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Because retatrutide is a younger compound with less-mature supply chains than semaglutide or tirzepatide, identity verification via mass spectrometry on the Janoshik COA is particularly critical

These differences may reflect expectations as much as outcomes: Younger adults appear more sensitive to side effects, cost, or the friction of staying on treatment, while older adults may weigh benefits differently

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They were randomly assigned in a 2:1 ratio, to 68 weeks of treatment with semaglutide (at a dose of 2.4 mg) or placebo, plus lifestyle intervention