Caruso U, Leone L, Cravotto E, et al
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244 In addition, tumor cells can consume a large amount of Met in the environment by highly expressing Met transporter SLC43A2, which can inhibit the Met metabolism of T cells in the microenvironment, resulting in the loss of dimethylation of histone H3K79me2 lysine 79 in T cells, low expression of STAT5, and inhibition of T cell function
In some embodiments, the otic formulation or composition comprises between about 0.01% to about 15% by weight of the cholesterol
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